1. The fifth letter of the modern English alphabet. 2. 3. The fifth in a series. 4. The third tone in the scale of C major or the fifth tone in the relative minor scale. 5. A key or scale in which E is the tonic. 6. A written or printed note representing this tone. 7. A string, key, or pipe tuned to the pitch of this tone. 8. A grade that indicates excellence in achievement or quality. 9. The base of the natural system of logarithms, having a numerical value of approximately 2.7183.